Base de dados : HANSEN Pesquisa : HANSENIASE VIRCHOWIANA/GENET [Descritor de assunto] Referências encontradas : 10 [refinar] Mostrando: 1 .. 10   no formato [Detalhado]

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Id: 27300 Autor: Soebono, Haryanto; Giphart, Marius J; Schreuder, Geziena M. T; Klatser, Paul R; Vries, Rene R. P. de. Título: Associations between HLA-DRB1 alleles and leprosy in an Indonesian population. Fonte: Int. J. Lepr;65(2):190-196, Jun. 1997. tab. Resumo: To investigate whether the susceptibility to leprosy (type), subclinical infection with Mycobacterium leprae and the antibody response against M. leprae-specific antigens are associated with HLA-DR phenotypes sequence-specific oligonucleotide HLA-DRB1 and DQA1 typing and antibody assays have been performed in 79 leprosy patients (41 TT/BT and 38 LL/BL) and 50 healthy controls from a Javanese population in Yogyakarta, Indonesia. DRB1*02 was associated with LL/BL [odds ratio (OR) 2.54, 95% confidence interval (CI) 0.97-9.78, p = 0.037 and attributable risk (AR) 41.5%] but not with TT/BT leprosy (p > 0.05). HLA-DRB1*12 was negatively associated with leprosy (either LL/BL or TT/BT [OR 0.33-0.35, p < 0.05, prevented fraction (PF) 58.8%-65.3%]. No significant association was found between HLA-DRB1 or DQA1 type, anti-M. leprae antibody level and subclinical infection with M. leprae. These data indicate that in this population susceptibility to lepromatous leprosy is associated with HLA-DRB1*02, while resistance to leprosy is associated with HLA-DRB1*12. These associations are not paralleled with associations of the same HLA types with anti-M. leprae antibody level. Finally, the results of this study also support the notion that infection with M. leprae per se is not associated with HLA-DRB1 or DQA1 alleles. (AU)^ien. Descritores: Hanseníase Dimorfa/genet Hanseníase Virchowiana/genet Hanseníase Tuberculóide/genet Antígenos HLA-DQ/genet Antígenos HLA-DR/genet Localização: BR191.1

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Id: 27135 Autor: Shu-Guang, Li; Vries, Rene RP. Título: HLA DQ molecules may be products of an immune suppression gene responsible for Mycobacterium leprae specific nonresponsiveness. Fonte: Int J Lepr;57(2):554-555, June 1989. ^bgraf, ^btab. Descritores: Hanseníase Virchowiana/genet Hanseníase Virchowiana/imunol Antígenos HLA-DQ/genet Antígenos HLA-DQ/imunol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n2/v57n2cor01.pdf - en. Localização: Br191.1

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Id: 27121 Autor: Abel, Laurent; Demenais, Florence; Baule, Marie-Sophie; Blanc, Madeleine; Muller, Anne; Raffoux, Colette; Millan, Jacques; Bois, Etienne; Babron, Marie-Claude; Feingold, Nicole. Título: Genetic susceptibility to leprosy on a Caribbean Island: linkage analysis with five markers. Fonte: Int J Lepr;57(2):465-471, June 1989. ^btab. Descritores: Alótipos da Imunoglobulina Gm/genet Alótipos de Imunoglobulina/genet Hanseníase/genet Hanseníase Virchowiana/genet Limites: Humanos Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n2/v57n2a02.pdf - en. Localização: Br191.1

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Id: 27026 Autor: Fafutis-Morris, Mary; Guillen-Vargas, Cecilia M; Navarro-Fierro, Sergio; Morales-Ortiz, Roberto; Armendariz-Borunda, Juan. Título: Serum IL-1ra is elevated in lepromatous leprosy patients. Fonte: Int. J. Lepr;67(3):287-291, Sept., 1999. tab. Resumo: Patterns of production of specific cytokines are accepted as standards for T-lymphocyte subsets in diseases caused by intracellular parasites. These lymphocyte subsets (Th1 and Th2) have been associated with the different poles of the leprosy spectrum. Lepromatous leprosy (LL) onset correlates with cytokines produced by Th2 cells on the grounds of the patient's poor cellular immune response, i.e., interleukin 2 (IL-2) and gamma interferon (IFN-gamma) deficiency. On the other hand, tuberculoid leprosy (TL) has been associated with a Th1 response. Moreover, pro-inflammatory cytokines like IL-1 beta and tumor necrosis factor-alpha (TNF-alpha) play a major role in chronic inflammatory pathologies being IL-1ra and TNF-alpha soluble receptors, natural counterbalancing inhibitors. In light of this background, we decided to measure serum levels of IL-1 beta, IL-1ra, TNF-alpha and IL-6 in LL and TL patients, and we also studied the production in vitro of Th1 (IFN-gamma, IL-2), Th2 (IL-4, IL-10) and TNF-alpha cytokines. Our data showed that IL-1ra is highly elevated in sera from LL patients; there were no differences in Th2 cytokine levels and there were diminished levels in Th1 cytokines. (AU)^ien. Descritores: Hanseníase Virchowiana/genet Hanseníase Virchowiana/imunol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1999/pdf/v67n3/v67n3a08.pdf - en. Localização: BR191.1

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Id: 26737 Autor: Shabaana, Abdul Khader; Venkatasubramani, Rajendran; Shanker Narayan, Nallakandypanangadan; Hoessli, Daniel C; Dharmalingam, Kuppamuthu. Título: Cytokine profiles in paraffin-embedded biopsy samples of lepromatous leprosy patients: semi-quantitative measure of cytokine mRNA using RT-PCR. Fonte: Int. J. Lepr;69(3):204-214, Sept., 2001. ilus, tab. Resumo: A reproducible technique for fixation of tissue, RNA extraction and reverse transcription polymerase chain reaction (RT-PCR) analysis from paraffin-embedded leprosy biopsies, has been developed and used to study the mRNA profiles. This approach is valuable in retrospective analysis of gene expression, and the handling of infectious biopsy material is also minimized. Among the methods of RNA extraction compared, the most efficient method was found to be incubation of the tissue sections in digestion buffer followed by extraction with Trizol. The experimental conditions were optimized for first strand cDNA synthesis and PCR, and used to measure the quantity of cytokine transcripts in biopsy materials. Interleukin-10 (IL-10) mRNA was detectable in all cases examined, which correlates well with other earlier reports using frozen tissues. However, IL-5 transcripts were present in 60% of the biopsies, unlike the earlier reports which showed IL-5 mRNA in all LL cases. Transforming growth factor-beta (TGF-beta) mRNA was detected in 80% of the biopsies, and this confirmed earlier immuno-cytochemical data which showed TGF-beta protein in all cases. Tumor necrosis factor-alpha mRNA was found in about 60% of the biopsies; whereas interferon gamma mRNA was detected in 30% of the LL cases. In conclusion, the results obtained in our study confirm and extend earlier observations which examined cytokines in peripheral blood cells and dermal lesions of leprosy. The simplicity of this method would allow the examination of a large number of samples across the spectrum of leprosy.(AU)^ien. Descritores: Hanseníase Virchowiana/genet Hanseníase Virchowiana/imunol Hanseníase Virchowiana/fisiopatol Citocinas/genet RNA Mensageiro/genet Reação em Cadeia da Polimerase Via Transcriptase Reversa/métodos Limites: Humanos Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2001/pdf/v69n3/v69n3a04.pdf - en. Localização: BR191.1

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Id: 25317 Autor: Kaplan, Gilla; Nusrat, Asma; Sarno, Euzenir N; Job, C. K; McElrath, Julie; Porto, Jarbas A; Nathan, Carl F; Cohn, Zanvil A Título: Cellular response to the intradermal injection of recombinant human gamma-interferon in lepromatous leprosy patients ..- Fonte: s.l; s.n; Aug. 1987. 9 p. ilus, tab. Resumo: The local response to single intradermal injection of 10 ug recombinat gamma-interferon (rIFNgamma) has been studied in 17 patients with lepromatous leprosy. Of these, 2 patients additionally received two intradermal injections of 10 ug rIFNgamma at received another site. The results were compared with those of 3 patients who received three injections of the same dose at a single site in an earlier study. One to 7 days after lymphokine administration 4-mm pinch biopsies were obtained and axamined for cellular alterations in the dermis and epidermis. This allowed a kinetic analysis of mononuclear cell infiltration, keratinocyte proliferation and differentiation and Langerhans cell redistribution. At 24 hours, the migration of large numbers of helper T cells and monocytes was already prominent and associated with induration. Mononuclear cell eccumulation peaked at 72 hours but then persisted for 5-7 days. Only smal numbers (one-third or less of toal T cells) of suppressor/cytotoxic T cells were present at any time, and granulocytes were absent. Two daily injections of rIFNgamma led to a more intense accumulation of cells. Ten ug of rIFNgamma resulted in enhanced keratinocyte proliferation, Ia expression, and thickening of the epidermis. At 24-48 hours major histocompatibility Class II (Ia) antigen was first noted on the dividing cells of the basal layer. By 72-96 hours the entire epidemir exhibited strong expression of Ia antigen on cell surfaces. Repeated doses of lymphokine accentuated these changes and resulted in a more prompt keratinization and sloughing of this layer. Whereas a single dose of rIFNgamma resulted in the upward movement of T6+ Langerhans cells (LCs) in the epidermis, two injections led to a 50% reduction in their numbers and three doses were associated with an almost total loss of detectable T6+ LCs from the epidermis. These are probably aloughed along with keratinocytes. In contrast to the situation with a delayed immune response in the skin (purified protein derivative), no LCs accumulated in the dermis in association with helper T cells (AU). Descritores: HANSENIASE VIRCHOWIANA/genet HANSENIASE VIRCHOWIANA/imunol HANSENIASE VIRCHOWIANA/microbiol HANSENIASE VIRCHOWIANA/fisiopatol INJECOES INTRADERMICAS/métodos INJECOES INTRADERMICAS/util CERATINOCITOS/citol CERATINOCITOS/imunol Limites: ESTUDO COMPARATIVO Localização: BR191.1; 09292/s

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Id: 18953 Autor: Bochud, Pierre-Yves; Hawn, Thomas R; Aderem, Alan Título: Cutting edge: a toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling ..- Fonte: s.l; s.n; 2003. 4 p. graf. Resumo: Toll-like receptors (TLRs) are key mediators of the innate immune response to microbial pathogens. We investigated the role of TLRs in the recognition of Mycobacterium leprae and the significance of TLR2Arg(677)Trp, a recently discovered human polymorphism that is associated with lepromatous leprosy. In mice, TNF-alpha production in response to M. leprae was essentially absent in TLR2-deficient macrophages. Similarly, human TLR2 mediated M. leprae-dependent activation of NF-kappaB in transfected Chinese hamster ovary and human embryonic kidney 293 cells, with enhancement of this signaling in the presence of CD14. In contrast, activation of NF-kappaB by human TLR2Arg(677)Trp was abolished in response to M. leprae and Mycobacterium tuberculosis. The impaired function of this TLR2 variant provides a molecular mechanism for the poor cellular immune response associated with lepromatous leprosy and may have important implications for understanding the pathogenesis of other mycobacterial infections. (AU). Descritores: CELULAS CHO LINHAGEM CELULAR IMUNIDADE NATURAL/genet ARGININA/genet HANSENIASE VIRCHOWIANA/genet HANSENIASE VIRCHOWIANA/imunol HANSENIASE VIRCHOWIANA/microbiol GLICOPROTEINAS DE MEMBRANA/defic GLICOPROTEINAS DE MEMBRANA/genet GLICOPROTEINAS DE MEMBRANA/fisiol CAMUNDONGOS ENDOGÂMICOS C57BL CAMUNDONGOS KNOCKOUT MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM TUBERCULOSIS/imunol POLIMORFISMO DE UM UNICO NUCLEOTIDIO/imunol TRANSDUCAO DE SINAL/imunol TRIPTOFANO/genet RECEPTORES DA SUPERFICIE CELULAR/defic RECEPTORES DA SUPERFICIE CELULAR/genet RECEPTORES DA SUPERFICIE CELULAR/fisiol Limites: HUMANO ANIMAL HAMSTERS CAMUNDONGOS SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Meio Eletrônico: - . Localização: BR191.1; 09085/s

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Id: 18504 Autor: Bleharski, Joshua R; Li, Huiying; Meinken, Christoph; Graeber, Thomas G; Ochoa, Maria-Teresa; Yamamura, Masahiro; Burdick, Anne; Sarno, Euzenir N; Wagner, Manfred; Röllinghoff, Martin; Rea, Thomas H; Colonna, Marco; Stenger, Steffen; Bloom, Barry R; Eisenberg, David; Modlin, Robert L Título: Use of genetic profiling in leprosy to discriminate clinical forms of the disease ..- Fonte: s.l; s.n; Sep. 2003. 4 p. graf. Resumo: Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens. (AU). Descritores: HANSENIASE VIRCHOWIANA/clas HANSENIASE VIRCHOWIANA/genet HANSENIASE VIRCHOWIANA/imunol HANSENIASE VIRCHOWIANA/fisiopatol HANSENIASE TUBERCULOIDE/clas HANSENIASE TUBERCULOIDE/genet HANSENIASE TUBERCULOIDE/imunol HANSENIASE TUBERCULOIDE/fisiopatol CITOCINAS/genet CITOCINAS/metab PERFILACAO DA EXPRESSÃO GÊNICA ANALISE POR CONGLOMERADOS CONTAGEM DE COLÔNIA MICROBIANA REGULACAO DA EXPRESSÃO GÊNICA IMUNIDADE CELULAR IMUNIDADE NATURAL MACROFAGOS ALVEOLARES/microbiol GLICOPROTEINAS DE MEMBRANA/imunol MYCOBACTERIUM TUBERCULOSIS/cresc MYCOBACTERIUM TUBERCULOSIS/imunol REACAO EM CADEIA DA POLIMERASE RECEPTORES IMUNOLOGICOS/genet RECEPTORES IMUNOLOGICOS/metab RECEPTORES DA SUPERFICIE CELULAR/imunol - REGULACAO PARA CIMA  Análise de Componente Principal  ALGORITMOS  GENES DE IMUNOGLOBULINAS  ANALISE DE SEQUÊNCIA COM SERIES DE OLIGONUCLEOTIDIOS Limites: SUPPORT, NON-U.S. GOV'T HUMANO SUPPORT, U.S. GOV'T, P.H.S. Meio Eletrônico: - . Localização: BR191.1; 09142/s; BR191.1; 09145/s

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Id: 18501 Autor: Lee, Seong-Beom; Kim, Byoung Chul; Jin, Song Hou; Park, Yong-Gyu; Kim, Se-Kom; Kang, Tae-Jin; Chae, Gue-Tae Título: Missense mutations of the interleukin-12 receptor beta 1(IL12RB1) and interferon-gamma receptor 1 (IFNGR1) genes are not associated with susceptibility to lepromatous leprosy in Korea ..- Fonte: s.l; s.n; 2003. 5 p. tab. Resumo: Interleukin-12 receptor beta 1 ( IL12RB1), interleukin-12 receptor beta 2 ( IL12RB2), and interferon gamma receptor 1 ( IFNGR1) perform important roles in the host defense against intracellular pathogens such as Mycobacteria. Several mutations within their genes have been confirmed as associated with increased susceptibility to mycobacterial infection. However, the association between mutations of the IL12RB1, IL12RB2, and IFNGR1 encoding genes and lepromatous leprosy has not been studied. This study screened for polymorphisms within IL12RB1, IL12RB2, and IFNGR1 encoding genes in the Korean populations using polymerase chain reaction (PCR)/single-strand conformation polymorphism (SSCP) DNA sequencing assay, and an association study was performed using the missense mutations of 705 A/G (Q214R), 1196 G/C (G378R), 1637 G/A (A525T), and 1664 C/T (P534S) of the IL12RB1, 83 G/A (V14M), and 1443 T/C (L467P) for the IFNGR1 encoding genes. There were no differences in the genotype and allele frequencies of IL12RB1 and IFNGR1 genes between 93 lepromatous leprosy patients and 94 control subjects. In conclusion, missense mutations of 705 A/G (Q214R), 1196 G/C (G378R), 1637 G/A (A525T), 1664 C/T (P534S) of the IL12RB1, 83 G/A (V14 M), and 1443 T/C (L467P) of the IFNGR1 encoding genes have no association with the susceptibility to lepromatous leprosy in the Korean population. (AU). Descritores: PREDISPOSICAO GENETICA PARA DOENÇA COREIA (GEOGRAFICO) HANSENIASE VIRCHOWIANA/etiol HANSENIASE VIRCHOWIANA/genet MUTACAO DE SENTIDO INCORRETO RECEPTORES DE INTERFERON/genet RECEPTORES DA INTERLEUCINA/genet Limites: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE IDOSO Meio Eletrônico: - . Localização: BR191.1; 09125/s

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Id: 18467 Autor: Kang, Tae Jin; Lee, Seong-Beom; Chae, Gue-Tae Título: A polymorphism in the toll-like receptor 2 is associated with IL-12 production from monocyte in lepromatous leprosy ..- Fonte: s.l; s.n; Oct. 2002. 7 p. graf. Resumo: Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacterial infections, and the mutations in the TLR2 have been shown to confer the susceptibility to infection with mycobacteria. We previously reported the detection of TLR2 Arg677Trp mutation in lepromatous leprosy. Here, the events triggered by TLR2 in response to cell lysate of Mycobacterium leprae(MLL), the causative agent of leprosy, were investigated. Upon stimulation with MLL, monocytes produced TNF-alpha and Interleukin-12 (IL-12), which play a role in the innate immune response to infection. Anti-TLR2 mAb blocked greater than 50 per cent of the MLL-induced production of IL-12. We also performed the functional study on TLR2 by measurement of IL-12 production in serum and monocytes from leprosy patients with TLR2 mutation (Arg677Trp). The monocytes obtained from patients with the TLR2 mutation, in comparison to the wild-type TLR2, is significantly less responsive to MLL. It was also confirmed that patients with TLR2 mutation showed significantly lower serum levels of IL-12, in comparing with TLR2 wild-type. Our results reveal that innate immune response of monocytes against M. lepraeis mediated by TLR2, and suggest that the mutation in the intracellular domain of TLR2 gene is associated with IL-12 production in lepromatous leprosy. (AU). Descritores: SEQUÊNCIA DE AMINOACIDOS SEQUÊNCIA DE BASES ESTUDOS DE CASOS E CONTROLES DNA COMPLEMENTAR/genet IMUNIDADE NATURAL INTERLEUCINA-12/bios HANSENIASE VIRCHOWIANA/genet HANSENIASE VIRCHOWIANA/imunol GLICOPROTEINAS DE MEMBRANA/quim GLICOPROTEINAS DE MEMBRANA/genet MONOCITOS/imunol MYCOBACTERIUM LEPRAE/imunol MUTACAO PUNTUAL POLIMORFISMO (GENETICA) ESTRUTURA TERCIARIA DE PROTEINA RECEPTORES DA SUPERFICIE CELULAR/quim RECEPTORES DA SUPERFICIE CELULAR/genet FATOR DE NECROSE TUMORAL/bios Limites: HUMANO SUPPORT, NON-U.S. GOV'T HUMANO IN VITRO Meio Eletrônico: - . Localização: BR191.1; 09004/s

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